Generic Name: carbinoxamine, dextromethorphan, and pseudoephedrine (kar bi NOX a meen/dex troe meh THOR fan/soo doe eh FEH drin)
Brand names: Andehist DM NR, Carb PSE 12 DM, Carbaxef-DM, Carbodex DM, Carbofed DM Drops, Cordron-12 DM, Cordron-DM NR, Mintex DM, Pediatex 12 DM, Pediatex-DM, PSE Allergy DM, PSE Carb DM Drops, PSE Carbinoxamine DM, Pseudo Carb DM, ...show all 28 brand names.
What is carbinoxamine, dextromethorphan, and pseudoephedrine?
Carbinoxamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Dextromethorphan is a cough suppressant. It suppresses an area in the brain that causes coughing.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of carbinoxamine, dextromethorphan, and pseudoephedrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.
Carbinoxamine, dextromethorphan, and pseudoephedrine may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about carbinoxamine, dextromethorphan, and pseudoephedrine?
Always ask a doctor before giving a cold or allergy medicine to a child, even if the medicine label provides dosing instructions for children. Death can occur from the misuse of cough and cold medicines in very young children. Do not use carbinoxamine, dextromethorphan, and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take carbinoxamine, dextromethorphan, and pseudoephedrine before the MAO inhibitor has cleared from your body. Carbinoxamine, dextromethorphan, and pseudoephedrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.
Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.
Do not take this product for cough caused by smoking, asthma, or emphysema. Do not take this medicine if your cough produces a lot of mucus, unless your doctor has told you to.
What should I discuss with my healthcare provider before taking carbinoxamine, dextromethorphan, and pseudoephedrine?
Do not use carbinoxamine, dextromethorphan, and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take carbinoxamine, dextromethorphan, and pseudoephedrine before the MAO inhibitor has cleared from your body.
Before taking this medication, tell your doctor if you are allergic to carbinoxamine, dextromethorphan, or pseudoephedrine, or if you have:
- kidney disease;
- liver disease;
diabetes;
glaucoma;
heart disease or high blood pressure;
thyroid disease;
a stomach ulcer or a stomach obstruction,
emphysema or chronic bronchitis; or
an enlarged prostate or urination problems.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Carbinoxamine, dextromethorphan, and pseudoephedrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.
How should I take carbinoxamine, dextromethorphan, and pseudoephedrine?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cold medicine is usually taken only for a short time until your symptoms clear up.
Always ask a doctor before giving a cold or allergy medicine to a child, even if the medicine label provides dosing intructions for children. Death can occur from the misuse of cough and cold medicines in very young children.
Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.
Store the medication at room temperature away from moisture and heat.
See also: Carbinoxamine, dextromethorphan, and pseudoephedrine dosage (in more detail)
What happens if I miss a dose?
Since cough and cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include extreme drowsiness, confusion, feeling restless or nervous, blurred vision, dry mouth, nausea, vomiting, restlessness, hallucinations, fainting, and seizure (convulsions).
What should I avoid while taking carbinoxamine, dextromethorphan, and pseudoephedrine?
This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Antihistamines, decongestants, and cough suppressants are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Tell your doctor if you regularly use other medicines that make you sleepy (such as narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by carbinoxamine or dextromethorphan.
Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
Carbinoxamine, dextromethorphan, and pseudoephedrine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
feeling light-headed, fainting;
urinating less than usual or not at all;
wheezing, tightness in your chest;
severe dizziness, anxiety, restless feeling, or nervousness;
easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).
Less serious side effects may include:
drowsiness, dizziness;
lack of coordination;
upset stomach;
stuffy nose, chest congestion;
sleep problems (insomnia);
feeling restless or excited (especially in children);
dry mouth or nose; or
blurred vision.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
Carbinoxamine, dextromethorphan, and pseudoephedrine Dosing Information
Usual Adult Dose for Cough:
Syrup:
5 mL orally four times a day as needed.
Liquid:
10 mL orally 4 times daily.
Suspension, extended release:
10 mL to 20 mL orally every 12 hours.
Usual Adult Dose for Nasal Congestion:
Syrup:
5 mL orally four times a day as needed.
Liquid:
10 mL orally 4 times daily.
Suspension, extended release:
10 mL to 20 mL orally every 12 hours.
Usual Pediatric Dose for Cough:
Syrup:
less than 2 years: safety and effectiveness unknown.
2 years to 5 years: 2.5 mL orally 4 times a day.
6 years to 18 years: 5 mL orally 4 times a day.
Liquid:
2 yrs to 5 yrs: 2.5 mL orally 4 times daily.
6 yrs to 11 yrs: 5 mL orally 4 times daily.
12 yrs or older: 10 mL orally 4 times daily.
Suspension, extended release:
2 yrs to 5 yrs: 2.5 mL to 5 mL orally every 12 hours
6 yrs to 11 yrs: 5 mL to 10 mL orally every 12 hours.
12 yrs or older: 10 mL to 20 mL orally every 12 hours.
Usual Pediatric Dose for Nasal Congestion:
Syrup:
less than 2 years: safety and effectiveness unknown.
2 years to 5 years: 2.5 mL orally 4 times a day.
6 years to 18 years: 5 mL orally 4 times a day.
Liquid:
2 yrs to 5 yrs: 2.5 mL orally 4 times daily.
6 yrs to 11 yrs: 5 mL orally 4 times daily.
12 yrs or older: 10 mL orally 4 times daily.
Suspension, extended release:
2 yrs to 5 yrs: 2.5 mL to 5 mL orally every 12 hours
6 yrs to 11 yrs: 5 mL to 10 mL orally every 12 hours.
12 yrs or older: 10 mL to 20 mL orally every 12 hours.
What other drugs will affect carbinoxamine, dextromethorphan, and pseudoephedrine?
Before taking carbinoxamine, dextromethorphan, and pseudoephedrine, tell your doctor if you are using any of the following drugs:
a diuretic (water pill), or blood pressure medicine;
medication to treat irritable bowel syndrome;
bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);
aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);
a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; or
antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.
This list is not complete and there may be other drugs that can interact with carbinoxamine, dextromethorphan, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
More carbinoxamine, dextromethorphan, and pseudoephedrine resources
- Carbinoxamine, dextromethorphan, and pseudoephedrine Side Effects (in more detail)
- Carbinoxamine, dextromethorphan, and pseudoephedrine Dosage
- Carbinoxamine, dextromethorphan, and pseudoephedrine Use in Pregnancy & Breastfeeding
- Carbinoxamine, dextromethorphan, and pseudoephedrine Drug Interactions
- Carbinoxamine, dextromethorphan, and pseudoephedrine Support Group
- 2 Reviews for Carbinoxamine, dextromethorphan, and pseudoephedrine - Add your own review/rating
Compare carbinoxamine, dextromethorphan, and pseudoephedrine with other medications
- Cough
- Nasal Congestion
Where can I get more information?
- Your pharmacist can provide more information about carbinoxamine, dextromethorphan, and pseudoephedrine.
See also: carbinoxamine, dextromethorphan, and pseudoephedrine side effects (in more detail)
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